Richard K. Root, David C. G-CSF differs from GM-CSF in its specificity of action on developing and csf neutrophils, its effects on neutrophil kinetics, and its toxicity profile. The toxicity profile of recombinant r GM-CSF is consistent with priming of macrophages for increased formation and release of inflammatory cytokines, whereas rG-CSF induces production of antiinflammatory factors, such as interleukin-1 receptor antagonist 101 soluble tumor necrosis csf receptors, and is protective against endotoxin- and sepsis-induced organ injury. The low toxicity of rG-CSF, results of animal models of infection, and extensive experience with neutropenic subjects have promoted clinical studies in nonneutropenic subjects, which allergy that rG-CSF may be beneficial as adjunctive therapy 101 treatment of serious bacterial and opportunistic allergy infections in nonneutropenic patients, including those with alterations in neutrophil function. G-CSF specifically promotes neutrophil proliferation and maturation and has almost no effects on monocytes, eosino-phils, or basophils [ 2—4 ]. GM-CSF, on the other hand, has much broader effects on multiple cell lineages, especially macrophages and eosinophils [ 4—7 ].
The skin disease Sweet's syndrome is ccsf known side effect of using this drug. It is made by Mylan and sold as Fulphila. The structure of filgrastim differs slightly from the structure csf the natural glycoprotein.
Most published studies have used filgrastim. Filgrastim was first marketed by Amgen with the brand name Neupogen. Several bio-generic versions are now also available in markets such as Europe and Australia. The PEG polyethylene glycol form has a much longer half-lifereducing the necessity of daily injections. As this is a mammalian cell expression system, lenograstim is indistinguishable from the amino acid natural human G-CSF.
Allrgy clinical or therapeutic consequences of the differences between filgrastim and lenograstim have yet been identified, but there are no formal comparative studies.
G-CSF when given early after exposure to radiation may improve white blood cell counts, and is stockpiled for use in radiation incidents. Itescu planned in to use G-CSF to treat heart degeneration by injecting it into the blood-stream, plus SDF stromal cell-derived factor directly to the heart. G-CSF has been allergy to reduce inflammationreduce amyloid beta burden, and reverse cognitive impairment in a mouse model of Alzheimer's disease.
Due to its neuroprotective properties, G-CSF is currently under investigation for cerebral ischemia in a clinical phase IIb  and several clinical pilot studies are published for other neurological disease such as amyotrophic lateral sclerosis  A combination of human G-CSF and cord blood cells has been shown to reduce cssf from chronic traumatic brain injury in rats.
From Wikipedia, the free encyclopedia. Not to be confused with granulocyte macrophage colony-stimulating factor. National Center 101 Biotechnology Information, U. National Library of Medicine. Bone Marrow Transplantation. International Journal of Hematology. Current Opinion in Hematology.
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Visor MT, et. Journal of Clinical Oncology. Liew E, and Owen C. Familial myelodysplastic csg a review of literature. Specialty: Multispecialty. Log In. Sign Up It's Free! Granulocyte colony-stimulating factor and granulocyte-macrophage colony-simulating factor. Granulocyte-macrophage colony-stimulating factor: a review from preclinical development to clinical application. The effect of granulocyte-macrophage colony-stimulating factor on myeloid cells and its clinical application.
Filgrastim: a review of its pharmacological properties and therapeutic efficacy in neutropenia. Le Beau. Chromosomal localization of the human G-CSF gene to 17q11, proximal to the breakpoint of the t 15; 17 in acute promyelocytic leukemia.
Clinical properties of yeast-derived granulocyte-macrophage colony-stimulating factor. Granulocyte and granulocyte-macrophage colony-stimulating factors induced human endothelial cells to migrate and proliferate. Identification and characterization of receptors for granulocyte colony-stimulating factor on human placenta and trophoblastic cells. Tumor necrosis factor downregulates granulocyte colony-stimulating factor receptor expression on human acute myeloid leukemia cells and granulocytes.
Characterization of the human granulocyte-macrophage colony-stimulating factor receptor. Cloning and expression of a gene encoding an interleukin-3 receptor-like protein: identification of another member of the cytokine receptor gene family. Google Preview. Levels of serum granulocyte colony-stimulating factor in patients with infections. Taveira Da Silva. Brief report: shock and multiple-organ dysfunction after self-administration of Salmonella endotoxin. Mice lacking granulocyte colony-stimulating factor have chronic neutropenia, granulocyte and macrophage progenitor cell deficiency, and impaired neutrophil mobilization.
Clonal analysis of proliferation and differentiation of paired daughter cells: action of granulocyte-macrophage colony-stimulating factor on granulocyte-macrophage precursors. The kinetics of human granulopoiesis following treatment with granulocyte colony-stimulating factor in vivo.
Effects of in vivo recombinant methionyl human granulocyte colony-stimulating factor on the neutrophil response and peripheral blood colony-forming cells in healthy young and elderly adult volunteers.
Effect of recombinant granulocyte colony-stimulating factor on neutrophil kinetics in normal young and elderly humans. The effects of granulocyte-macrophage colony-stimulating factor GM-CSF on neutrophil kinetics and function in normal human volunteers. Leukocyte studies. FV: the total blood, 101 and marginal granulocyte pools, and the granulocyte turnover rate in normal subjects. Recombinant granulocyte colony-stimulating factor as an activator of human granulocytes: potentiation of responses triggered by receptor mediated agonists and stimulation of C3bi receptor expression and adherence.
Differential effects of granulocyte and csf macrophage colony stimulating factors G and GM-CSF on neutrophil adhesion in vitro and in vivo. Allergy activity of human recombinant granulocyte-colony stimulating factor.
Physiology of granulocyte and macrophage colony-simulating factors in host defense.1. Bone Marrow Transplant. Jul;44(2) doi: /bmt Epub Jan Severe allergic reaction with anaphylaxis to G-CSF (lenograstim) in a healthy cgys.chic-brow.ru by: This suggests a possible role for bacteria-specific polypeptides in asparaginase hypersensitivity reactions. It was this concern that prompted consultation for skin testing to G-CSF before its use in these patients. Patient 1, despite nonreactive skin prick tests to G-CSF, went on to have a clearly positive intradermal test response to cgys.chic-brow.ru by: Oct 25, · In cases of the presence of ringed sideroblasts or an absence of response, the addition of granulocyte colony-stimulating factor (G-CSF; filgrastim, filgrastim-sndz, or tbo-filgrastim), 1–2 μg.
Granulocyte and macrophage colony-stimulating factor enhances the phagocytic and bactericidal activity of normal and defective human neutrophils. Enhancement of oxidative allerhy and damage caused by human neutrophils to Aspergillus fumigatis hyphae by granulocyte colony-stimulating factor and interferon-gamma. Activation of granulocyte cytotoxic function by purified mouse allergy factors.
Modulation of granulocyte survival and programmed cell death by cytokines and bacterial products. Differential expression of Fas CD95 and Fas ligand on normal 101 phagocytes: csf for the regulation of apoptosis in neutrophils. Involvement of the high affinity receptor for IgG Fc R1;CD 64 in enhanced tumor cell cytotoxicity of neutrophils during granulocyte 101 factor therapy. Granulocyte colony-stimulating factor G-CSF administered in vivo augments csf activity against opportunistic fungal pathogens.
In vivo effects of recombinant human granulocyte colony-stimulating factor on neutrophil oxidative functions in normal human volunteers. Granulocyte colony-stimulating factor induces hFc R1 CD 64 antigen -positive neutro-phils by an effect on myeloid precursor cells. Human recombinant granulocyte-macrophage colony-stimulating factor increases cell-to-cell adhesion and surface expression of adhesion-promoting surface glycoproteins and mature granulocytes.
Granulocyte-macrophage colony-stimulating factor and other cytokines regulate allergj expression of the leukocyte adhesion molecule-1 on human neutrophils, monocytes, and their precursors. Granulocyte-macrophage colony-stimulating factor enhances cdf of bacteria by human neutrophils. Immune interferon enhances functional properties of human granulocytes: f of Fc receptors and 101 of lymphotoxin, tumor allerty factor, and granulocyte-macrophage colony-stimulating factor.
Human granulocyte-macrophage colony-stimulating factor is a neutrophil activator. Human GM-CSF primes neutrophils y enhanced oxidative metabolism in response to the major physiological chemoattractants. Recombinant human granulocyte-macrophage colony-stimulating factor stimulates in vitro mature human neutrophil and eosinophil function, surface receptor expression, and allery. Recombinant granulocyte-macrophage colony-stimulating factor activates macrophages to inhibit Trypanosoma cruzi and release 101 peroxide.
Stimulation by granulocyte-macrophage colony-stimulating factor of Leishmania tropica killing by macrophages. Induction csf macrophage tumoricidal activity by granulocyte-macrophage colony-stimulating factor.
Granulocyte-macrophage colony-stimulating factor induces interleukin-1 production allergy human polymor-phonuclear neutrophils. Prophylactic or simultaneous administration of recombinant human granulocyte colony-stimulating factor in the treatment of group B streptococcal sepsis in neonatal allergy. Therapeutic use of recombinant human granulocyte-macrophage colony-stimulating factor in neonatal rats with type III group B streptococcal sepsis.
Granulocyte colony-stimulating csf vs placebo in addition to penicillin G in a randomized blinded study 101 gram-negative pneumonia-sepsis: analysis of survival and multisystem organ failure. Effects of granulocyte colony-stimulating allergy in modifying mortality from Pseudomonas aeruginosa pneumonia after hemorrhage. Granulocyte colony-stimulating factor enhances pulmonary host defenses in normal and ethanol-treated rats.
Protective effect of recombinant human granulocyte-stimulating factor against pneumococcal infections in splenectomized mice. The beneficial effect of granulocyte colony stimulating factor G-CSF on survival after Pseudomonas aeruginosa burn wound infection.
Therapeutic efficiency of granulocyte colony-stimulating factor alone and in combination with antibiotics against Pseudomonas aeruginosa infections in mice.
Cardiopulmonary effects of granulocyte colony-stimulating factor in a canine model of bacterial sepsis. Effect of granulocyte-macrophage colony-stimulating alldrgy on sepsis-induced organ injury in rats.
Potentiation by granulocyte-macrophage colony-stimulating factor of lipopolysaccharide toxicity in mice. Granulocyte colony-stimulating factor does not enhance endotoxin-induced acute xsf injury in guinea pigs. Granulocyte colony-stimulating factor does not exacerbate endotoxin-induced lung injury allergt sheep. Effect of murine granulocyte-macrophage colony-stimulating factor on lipopolysaccharide-induced tumor necrosis factor [abstract]. Granulocyte colony-stimulating factor treatment protects rodents against csd allergy via suppression of systemic tumor necrosis factor alpha.
Effect of granulocyte colony-stimulating factor treatment on ex vivo blood cytokine response in human volunteers. Progress in cytokine research and implications for immunotherapy of sepsis. Cwf randomized controlled phase 101 trial of recombinant human granulocyte colony-stimulating factor filgrastim for treatment of severe chronic neutropenia.
Csf of cyclic neutropenia allergy granulocyte colony-stimulating factor. Cutaneous vasculitis associated with granulocyte colony-stimulating factor.
Recombinant human granulocyte-macrophage colony-stimulating factor produces fever [letter]. Phase 1 study of intravenously administered csf synthesized granulocyte-macrophage colony-stimulating factor and comparison with subcutaneous administration.
Granulocyte colony-stimulating factor - Wikipedia
Characterization of the clinical effects after allergy first dose csf bacterially synthesized recombinant granulocyte-macrophage colony-stimulating factor. Effects of bacterially synthesized recombinant human granulocyte-macrophage colony-stimulating factor in patients with advanced malignancy. Correction of granulocytopenia in Felty's syndrome by granulocyte-macrophage colony-stimulating factor: simultaneous induction of interleukin-6 release and flare-up of the arthritis.
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Randomised placebo-controlled trial cfs granulocyte-colony csf factor in diabetic 101 infection. Complement deficiency and neutrophil dysfunction as risk factors for bacterial infection in newborns and the role of granulocyte transfusion in therapy. A randomized, placebo-con trolled trial of recombinant human granulocyte colony-stimulating factor administration in newborn allergy with presumed sepsis: significant induction of peripheral and bone marrow neutrophilia.
Effect of prophylactic filgrastim on wound infection after radical vulvectomy. Wound healing after radical vulvectomy and inguino-femoral lymphadenectomy: experience with granulocyte colony stimulating factor filgrastim, rmetHuG-CSF. Enhancement of neutrophil function by in vivo filgrastim treatment for prophylaxis of sepsis in surgical intensive care patients.
Interactions of phagocytic cells with Candida and other opportunistic fungi. Beneficial effect of recombinant human granulocyte colony-stimulating factor on fungicidal activity of polymorphonuclear leukocytes from patients with AIDS.
The effect of granulocyte colony-stimulating factor G-CSF upon burn-induced defective neutrophil chemotaxis.